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(1993) A predic-tive index for functional decline in hospitalized elderly medicalpatients. Mevalonatepathway genes are induced upon mutant p53 recruitment to Sterol RegulatoryElement (SRE) on target promoters, in a process that depends on SRE bindingproteins ?1 and ?2 (SREBP). The location of certain tumors to eloquent neurologic structuresincreases the risk of postoperative de?cits.
In those instances where metabolismresults in bioactivation of a drug or xenobiotic, inhibitorswill decrease the pharmacological or toxic effect.
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